The Hippo signaling pathway in development and regeneration.

The Hippo signaling pathway is a central growth control mechanism in multicellular organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo pathway orchestrates proliferation, survival, differentiation, and mechanics of cells, which in turn regulate organ development, homeostasis, and regeneration. A deep understanding of the regulation and function of the Hippo pathway therefore holds great promise for developing novel therapeutics in regenerative medicine. Here, we provide updates on the molecular organization of the mammalian Hippo signaling network, review the regulatory signals and functional outputs of the pathway, and discuss the roles of Hippo signaling in development and regeneration. Zhong et al. provide a comprehensive review of the mammalian Hippo signaling pathway. The composition, architecture, and upstream cues of the signaling network are analyzed. Moreover, a concept of helper and worker cell is proposed, and its implications in the development and regeneration of selected organs are discussed. [ABSTRACT FROM AUTHOR]