Skin photoageing following sun exposure is associated with decreased epigenetic and biologic age, and correlates with basal cell carcinoma phenotype.

This article discusses a study that examines the relationship between sun exposure, skin aging, and basal cell carcinoma (BCC). The study used DNA methylation data from sun-exposed and sun-protected skin samples, as well as BCC samples, to analyze epigenetic and biological age, and telomere length. The results show that sun-exposed skin has a slower epigenetic and biological aging process and shorter telomeres compared to sun-protected skin. These effects were more common in older individuals and females. The study suggests that these age dysregulation patterns may indicate an increased risk of skin cancer after prolonged sun exposure. The study was funded by various sources and the authors have no conflicts of interest. [Extracted from the article]