Back to Search Start Over

Exploring DNA Damage and Repair Mechanisms: A Review with Computational Insights.

Authors :
Chen, Jiawei
Potlapalli, Ravi
Quan, Heng
Chen, Lingtao
Xie, Ying
Pouriyeh, Seyedamin
Sakib, Nazmus
Liu, Lichao
Xie, Yixin
Source :
BioTech; Mar2024, Vol. 13 Issue 1, p3, 12p
Publication Year :
2024

Abstract

DNA damage is a critical factor contributing to genetic alterations, directly affecting human health, including developing diseases such as cancer and age-related disorders. DNA repair mechanisms play a pivotal role in safeguarding genetic integrity and preventing the onset of these ailments. Over the past decade, substantial progress and pivotal discoveries have been achieved in DNA damage and repair. This comprehensive review paper consolidates research efforts, focusing on DNA repair mechanisms, computational research methods, and associated databases. Our work is a valuable resource for scientists and researchers engaged in computational DNA research, offering the latest insights into DNA-related proteins, diseases, and cutting-edge methodologies. The review addresses key questions, including the major types of DNA damage, common DNA repair mechanisms, the availability of reliable databases for DNA damage and associated diseases, and the predominant computational research methods for enzymes involved in DNA damage and repair. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
26736284
Volume :
13
Issue :
1
Database :
Complementary Index
Journal :
BioTech
Publication Type :
Academic Journal
Accession number :
176272605
Full Text :
https://doi.org/10.3390/biotech13010003