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FeCl3/KI‐Catalyzed Tandem Oxidative Cyclization for Switchable Total Synthesis of Luotonin A, B and Derivatives.
- Source :
- Advanced Synthesis & Catalysis; 3/19/2024, Vol. 366 Issue 6, p1348-1355, 8p
- Publication Year :
- 2024
-
Abstract
- A total synthesis strategy was developed for the synthesis of luotonin A, B and their analogues using synergistic FeCl3/KI‐catalyzed oxidative cyclization. This protocol utilizes cheap and widely available N‐propargyl 2‐methyl‐quinazolinones and arylamines under mild conditions, and it has a wide substrate scope and high atom economy. Different natural products (luotonin A, B and derivatives) can be synthesized via a unique switchable approach. Further transformations from luotonin B to luotonin E and structural modification of natural products demonstrate the potential applications of this method. Moreover, camptothecin can also be modified with the reported protocol to afford the hydroxyl‐substituted product. [ABSTRACT FROM AUTHOR]
- Subjects :
- RING formation (Chemistry)
NATURAL products
AROMATIC amines
ALKALOIDS
CAMPTOTHECIN
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 366
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 176295544
- Full Text :
- https://doi.org/10.1002/adsc.202301322