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Procalcitonin and Presepsin as Markers of Infectious Respiratory Diseases in Children: A Scoping Review of the Literature.
- Source :
- Children; Mar2024, Vol. 11 Issue 3, p350, 20p
- Publication Year :
- 2024
-
Abstract
- Introduction: Procalcitonin and presepsin have been suggested to be able to discriminate bacterial and viral infections, also in children. This scoping review aims to better explore the available evidence around the potential role of these biomarkers in the subgroup of children with respiratory infectious diseases. Methods: We performed a systematic scoping review of studies published until March 2023 in the following bibliographic databases: PubMed, EMBASE, Cochrane and SCOPUS. Results: In children with bacterial infection, procalcitonin values ranged from 0.5 ng/mL to 8.31 ng/dL, while in those hospitalized in an intensive care unit ranged from 0.6 ng/dL to 452.8 ng/dL with PCR from 2 ng/dL to 51.7 ng/dL. In children with viral infections, procalcitonin value values ranged from 0.2 ng/dL to 0.84 ng/dL, while in those hospitalized in an intensive care unit ranged from 0.61 ng/dL to 46.6 ng/dL. No studies on presepsin in children with respiratory infections were retrieved. Conclusions: Although the available literature is highly heterogeneous, evidence does not suggest a role of procalcitonin in accurately differentiating bacterial and viral infections in children with respiratory infections. In future, new approaches based on multiple markers may better help determine which febrile children require antibiotics. [ABSTRACT FROM AUTHOR]
- Subjects :
- VIRAL disease diagnosis
DIAGNOSIS of bacterial diseases
PREDICTIVE tests
MEDICAL information storage & retrieval systems
RESPIRATORY infections
STAPHYLOCOCCAL diseases
CALCITONIN
SEVERITY of illness index
SYSTEMATIC reviews
MEDLINE
LITERATURE reviews
MEDICAL databases
ONLINE information services
STREPTOCOCCAL diseases
MEMBRANE proteins
BIOMARKERS
C-reactive protein
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 22279067
- Volume :
- 11
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Children
- Publication Type :
- Academic Journal
- Accession number :
- 176304045
- Full Text :
- https://doi.org/10.3390/children11030350