Back to Search
Start Over
Effect of metformin on anti-mullerian hormone levels in women with polycystic ovarian syndrome: a systematic review and meta-regression analysis of randomized controlled trials with.
- Source :
- BMC Endocrine Disorders; 3/29/2024, Vol. 24 Issue 1, p1-10, 10p
- Publication Year :
- 2024
-
Abstract
- Background: Several interventional studies have evaluated the potential anti-Mullerian hormone (AMH)-reduction effect of metformin. However, the results are still contradictory. In order to obtain a better viewpoint from them, this study aimed to comprehensively investigate the effects of metformin on AMH in the women with with polycystic ovarian syndrome (PCOS). Methods: Scopus, PubMed/Medline, Web of Science, Cochrane, and Embase databases were searched using standard keywords to identify all controlled trials investigating the AMH levels following metformin administration. Pooled weighted mean difference and 95% confidence intervals were achieved by random-effects model analysis for the best estimation of outcomes. Results: Sixteen studies with 484 participants' were included in this article. The pooled findings showed that AMH levels in the single arm clinical trials were significantly reduced (pooled WMD of -3.06 ng/ml; 95% confidence interval [CI] -4.03 to -2.10; P < 0.001) after use of metformin. Furthermore, compared to the control group, in randomized clinical trials, a reduced significant effect on AMH levels was observed following use of metformin (pooled WMD of -3.47 ng/ml; 95% CI -7.14 to -0.19; P = 0.047). Furthermore, higher reduction in the AMH levels with a metformin dosage ≤ 1500 mg/day and duration of treatment ≤ 12 weeks when compared to higher dosages and duration of intervention, observed in this meta-analysis. Conclusions: In conclusion, results this meta-analysis of clinical trials confirms the beneficial effect of the treatment with metformin in the reduction of the AMH levels in women. [ABSTRACT FROM AUTHOR]
- Subjects :
- METFORMIN
SEX hormones
MEDICAL information storage & retrieval systems
POLYCYSTIC ovary syndrome
TREATMENT effectiveness
META-analysis
DESCRIPTIVE statistics
TREATMENT duration
SYSTEMATIC reviews
MEDLINE
MEDICAL databases
WOMEN'S health
ONLINE information services
CONFIDENCE intervals
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 14726823
- Volume :
- 24
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Endocrine Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 176340081
- Full Text :
- https://doi.org/10.1186/s12902-024-01570-z