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Reference curves of motor function outcomes in young steroid‐naïve males with Duchenne muscular dystrophy.

Reference curves of motor function outcomes in young steroid‐naïve males with Duchenne muscular dystrophy.

Authors :
Hoskens, Jasmine
Schiava, Marianela
Goemans, Nathalie
Feys, Hilde
McDermott, Michael P.
Martens, William B.
Mayhew, Anna
Griggs, Robert C.
Klingels, Katrijn
Guglieri, Michela
Source :
Developmental Medicine & Child Neurology; May2024, Vol. 66 Issue 5, p644-653, 10p
Publication Year :
2024

Abstract

Aim: To investigate functional motor performance in a large cohort of young steroid‐naïve males with Duchenne muscular dystrophy (DMD) and typically developing males, and to develop specific reference curves for both groups. Also, to describe associations between anthropometric values and functional motor outcomes. Method: Cross‐sectional data of 196 steroid‐naïve males with DMD aged 4 to 8 years and 497 typically developing males aged 2 years 6 months to 8 years were included. Both groups were evaluated with the time to rise from the floor test, 10‐metre walk/run test, 6‐minute walk test, and North Star Ambulatory Assessment. Reference curves with centiles 5%, 10%, 25%, 50%, 75%, 90%, and 95% were estimated using quantile regression. Results: Males with DMD scored significantly worse on all functional motor outcomes than age‐matched typically developing males (p < 0.001): 89% to 95% of the males with DMD scored below the 5th centile of the typically developing males. No or weak correlations exist between anthropometric values and functional motor outcomes. Interpretation: The estimated reference curves can support consultation with families of young males with DMD and can support the evaluation of treatment for reaching motor skills and functional motor outcomes compared with typically developing males. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00121622
Volume :
66
Issue :
5
Database :
Complementary Index
Journal :
Developmental Medicine & Child Neurology
Publication Type :
Academic Journal
Accession number :
176353195
Full Text :
https://doi.org/10.1111/dmcn.15788