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A rare case of isoniazid mono-resistant tuberculosis presenting as cardiac tamponade along with an anterior mediastinal mass in a 15-year-old immunocompetent patient.
- Source :
- Lung India; Mar/Apr2024, Vol. 41 Issue 2, p130-134, 5p
- Publication Year :
- 2024
-
Abstract
- A 15-year-old boy presented with a sudden onset of breathlessness for 7 days, gradual loss of weight of 17.6 lbs over the last month and progressive hoarseness of voice for 7 months. The contrast-enhanced computed tomography (CECT) scan revealed a heterogeneously enhancing lesion in the anterior mediastinum with multiple discrete lymph nodes in the cervical and mediastinal locations. The GeneXpert MTB/RIF assay performed on the CT-guided biopsy of the mass was negative, but the culture for Mycobacterium tuberculosis was positive at 7 weeks of incubation. There was a suboptimal radiological response after 6 months of treatment. First-line drug susceptibility testing (DST) performed by line probe assay (LPA) on the positive culture detected high-level resistance to isoniazid. The treatment was modified as per DST results to which the patient responded well. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09702113
- Volume :
- 41
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Lung India
- Publication Type :
- Academic Journal
- Accession number :
- 176419909
- Full Text :
- https://doi.org/10.4103/lungindia.lungindia_221_23