University of the Witwatersrand Reports Findings in HIV/AIDS (Effects of injectable contraception with depot medroxyprogesterone acetate or norethisterone enanthate on estradiol levels and menstrual, psychological and behavioral measures...).

A report from the University of the Witwatersrand in South Africa discusses the effects of two injectable contraceptives, depot medroxyprogesterone acetate (DMPA-IM) and norethisterone enanthate (NET-EN), on estradiol levels and various measures related to HIV risk. The study found that both contraceptives significantly reduced estradiol levels and had different effects on menstrual, psychological, and behavioral measures. NET-EN users reported fewer instances of amenorrhea, fewer sexual acts, more condom use with steady partners, and more days feeling sad or unloved compared to DMPA-IM users. The study suggests that a randomized trial is needed to further investigate the impact of these contraceptives on HIV risk. [Extracted from the article]