From autism to Alzheimer's: A large-scale animal study links brain pH changes to wide-ranging cognitive issues.

A groundbreaking research paper submitted to eLife by a global collaborative research group reveals that altered brain pH and lactate levels are common hallmarks in numerous animal models of neuropsychiatric and neurodegenerative disorders. The study, which encompasses 109 strains/conditions of mice, rats, and chicks, demonstrates that changes in brain pH and lactate levels are prevalent in a diverse range of animal models of diseases such as schizophrenia, bipolar disorder, autism, depression, epilepsy, and Alzheimer's disease. The research suggests that altered energy metabolism may be a key factor in these disorders and could potentially lead to the development of new approaches for treatment. [Extracted from the article]