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Dendritic Cell-Based Immunotherapy: The Importance of Dendritic Cell Migration.
- Source :
- Journal of Immunology Research; 4/8/2024, Vol. 2024, p1-11, 11p
- Publication Year :
- 2024
-
Abstract
- Dendritic cells (DCs) are specialized antigen-presenting cells that are crucial for maintaining self-tolerance, initiating immune responses against pathogens, and patrolling body compartments. Despite promising aspects, DC-based immunotherapy faces challenges that include limited availability, immune escape in tumors, immunosuppression in the tumor microenvironment, and the need for effective combination therapies. A further limitation in DC-based immunotherapy is the low population of migratory DC (around 5%–10%) that migrate to lymph nodes (LNs) through afferent lymphatics depending on the LN draining site. By increasing the population of migratory DCs, DC-based immunotherapy could enhance immunotherapeutic effects on target diseases. This paper reviews the importance of DC migration and current research progress in the context of DC-based immunotherapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- DENDRITIC cells
CELL migration
IMMUNOTHERAPY
IMMUNE response
LYMPH nodes
Subjects
Details
- Language :
- English
- ISSN :
- 23148861
- Volume :
- 2024
- Database :
- Complementary Index
- Journal :
- Journal of Immunology Research
- Publication Type :
- Academic Journal
- Accession number :
- 176508967
- Full Text :
- https://doi.org/10.1155/2024/7827246