Researchers Submit Patent Application, "Sodium Thiosulfate-Containing Pharmaceutical Compositions", for Approval (USPTO 20240101422).

Researchers from Hope Medical Enterprises Inc. have submitted a patent application for "Sodium Thiosulfate-Containing Pharmaceutical Compositions." The application addresses the need for purified sodium thiosulfate pentahydrate that meets FDA quality standards, as the currently available sodium thiosulfate pentahydrate does not meet these requirements. The application also discusses the lack of an effective analytical method for determining total non-purgeable organic carbon in a sodium thiosulfate pentahydrate-containing sample. The inventors provide methods for preparing sodium thiosulfate, determining non-purgeable organic carbon, and treating acute poisonings. The patent application further explores the use of sodium thiosulfate in treating or preventing various medical conditions, such as platinum-induced ototoxicity and nephrotoxicity, calciphylaxis, vascular calcification, and dermatological diseases or conditions associated with the skin. The methods involve administering pharmaceutical grade sodium thiosulfate in therapeutically effective amounts, with detailed specifications provided for the composition of the sodium thiosulfate used. [Extracted from the article]