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Role of reactive oxygen species in myelodysplastic syndromes.

Authors :
Jing, Qiangan
Zhou, Chaoting
Zhang, Junyu
Zhang, Ping
Wu, Yunyi
Zhou, Junyu
Tong, Xiangmin
Li, Yanchun
Du, Jing
Wang, Ying
Source :
Cellular & Molecular Biology Letters; 4/14/2024, Vol. 29 Issue 1, p1-38, 38p
Publication Year :
2024

Abstract

Reactive oxygen species (ROS) serve as typical metabolic byproducts of aerobic life and play a pivotal role in redox reactions and signal transduction pathways. Contingent upon their concentration, ROS production not only initiates or stimulates tumorigenesis but also causes oxidative stress (OS) and triggers cellular apoptosis. Mounting literature supports the view that ROS are closely interwoven with the pathogenesis of a cluster of diseases, particularly those involving cell proliferation and differentiation, such as myelodysplastic syndromes (MDS) and chronic/acute myeloid leukemia (CML/AML). OS caused by excessive ROS at physiological levels is likely to affect the functions of hematopoietic stem cells, such as cell growth and self-renewal, which may contribute to defective hematopoiesis. We review herein the eminent role of ROS in the hematological niche and their profound influence on the progress of MDS. We also highlight that targeting ROS is a practical and reliable tactic for MDS therapy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14258153
Volume :
29
Issue :
1
Database :
Complementary Index
Journal :
Cellular & Molecular Biology Letters
Publication Type :
Academic Journal
Accession number :
176582234
Full Text :
https://doi.org/10.1186/s11658-024-00570-0