Clinical practice guidelines for esophagogastric junction cancer: Upper GI Oncology Summit 2023.

This document provides clinical practice guidelines for the treatment of esophagogastric junction (EGJ) cancer. The guidelines were developed through an international consensus meeting and are intended for clinicians, healthcare professionals, and patients. The recommendations are based on a systematic review of the literature and were determined through a voting process. The document discusses various clinical questions related to the surgical management of EGJ cancer, including surgical approaches, lymph node dissection, minimally invasive surgery, and surgical resection for oligo-metastasis. The evidence level for these recommendations is weak, and further research is needed. The document also discusses the use of white light endoscopy alone versus combined with image-enhanced endoscopy for the detection of superficial neoplasia at the gastroesophageal junction zone. It concludes that white light endoscopy alone is recommended for detection, but other modalities may improve tumor detection rates. The document also provides recommendations for chemotherapy regimens for patients with esophagogastric junction adenocarcinoma and esophageal adenocarcinoma, as well as the importance of biomarker testing before first-line chemotherapy. [Extracted from the article]