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Comparison of IgG-Predominant Antibody Responses between Conventional Inactivated and mRNA SARS CoV-2 Vaccines Administrated in Jordan.
- Source :
- Journal of Medicinal & Chemical Sciences; Apr2024, Vol. 7 Issue 4, p626-636, 11p
- Publication Year :
- 2024
-
Abstract
- Introduction: Different COVID-19 vaccines can affect various body systems, including the immune system, leading to distinctions in immune responses like natural killer cell cytotoxic activity, complement system function, and B-cell antibody production among vaccinated and nonvaccinated individuals. In Jordan, so far, there is no study exploring these immune response variations for four COVID-19 vaccines, along with the factors influencing the response and post-vaccination clinical outcomes. Methods: This study focuses on the humoral responses of 350 adult participants. Through participant interviews, one blood sample was collected for subsequent laboratory testing, utilizing the Enzyme-Linked Immunosorbent Assay (ELISA) method to examine the presence of COVID-19 antibodies in participants' plasma. A Chi-square test was performed to test for the statistical significance. Results: Our results indicate significant differences in positive antibody response efficiency (p value > 0.001) among participants who received two or three doses of COVID-19 inactivated and mRNA vaccines. The order of higher positive antibody frequency is as follows: Pfizer (90.5%), Sputnik V (88.1%), Sinopharm (78.8%), and AstraZeneca (65.8%). There is a noticeable inclination towards the efficacy of the Pfizer-BioNTech vaccine, evidenced by the highest levels of antibodies in recipients of this vaccine. Our study revealed that various factors, including gender, age, and smoking status prior to infection, play a role in significant contributors affecting immune response and influencing the effectiveness of these vaccines. Conclusion: All the four types of COVID-19 vaccines administered in Jordan demonstrated effectiveness. We recommend studying the ability of B lymphocytes present in the peripheral blood and the effect of Tregulatory cells by flow cytometry in recipients who have high positive titers. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 26453495
- Volume :
- 7
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Medicinal & Chemical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 176621560
- Full Text :
- https://doi.org/10.26655/JMCHEMSCI.2024.4.7