Feasibility of endoscopic ultrasound-guided fine needle biopsy for generating patient-derived organoids of pancreatic ductal adenocarcinoma: preliminary results from a single-center prospective database.

This article discusses the feasibility of using endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) to generate patient-derived organoids (PDOs) of pancreatic ductal adenocarcinoma (PDAC). PDOs are three-dimensional models of human tumors that can be used for research purposes. The study found that PDAC-PDOs could be successfully generated through EUS-FNB sampling with a single-pass fine needle biopsy, without any adverse events occurring. The success rate of generating PDAC-PDOs was 43%, and sample adequacy and diagnostic rates were both achieved in 100% of subjects. [Extracted from the article]