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Prognosis of amyotrophic lateral sclerosis patients after tracheostomy invasive ventilation in Korea.
- Source :
- Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration; May2024, Vol. 25 Issue 3/4, p271-281, 11p
- Publication Year :
- 2024
-
Abstract
- Background: Tracheostomy invasive ventilation (TIV) is applied to a subset of amyotrophic lateral sclerosis (ALS) patients; however, its frequency and impact on prognosis vary across countries. Methods: We conducted a nationwide retrospective cohort study using Korean National Health Insurance claims data. All patients diagnosed with sporadic ALS from 2012 to 2017 were included, with the observation period until 2020. The survival time between the TIV and non-TIV groups was compared using propensity score matching analysis, and prognostic factors were assessed within the TIV group. Results: This study included 3484 ALS patients (mean [standard deviation] age, 62.4 [11.9] years, 60.4% male), among whom 1230 (35.3%) underwent TIV. After 1:1 propensity score matching, the survival duration between the two groups was not significantly different (28 vs. 25 months, p = 0.057). Cox regression indicated that older age (hazard ratios [HRs] for each decade compared to <40 years: 3.89, 3.83, 5.30, 6.78, and 8.40 [ ≥ 80 years]; p < 0.005 for all) and lower income (HR, 1.28; 95% confidence interval [CI], 1.09–1.52; p = 0.003) negatively impacted survival, while gastrostomy (HR, 0.57; 95% CI, 0.50–0.66; p < 0.001) and supportive care services (HR, 0.43; 95% CI, 0.32–0.59; p < 0.001) were associated with prolonged survival. Conclusions: TIV was administered to more than one-third of Korean ALS patients without significant survival prolongation. Older age, lower income, lack of gastrostomy, and insufficient supportive care were independent poor prognostic factors for survival, underscoring the importance of comprehensive management for ALS patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 21678421
- Volume :
- 25
- Issue :
- 3/4
- Database :
- Complementary Index
- Journal :
- Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
- Publication Type :
- Academic Journal
- Accession number :
- 176695489
- Full Text :
- https://doi.org/10.1080/21678421.2024.2314064