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Efficacy of nonpharmacological interventions for severe radiation‐induced oral mucositis among head and neck cancer patients: A network meta‐analysis of randomised controlled trials.
- Source :
- Journal of Clinical Nursing (John Wiley & Sons, Inc.); Jun2024, Vol. 33 Issue 6, p2030-2049, 20p
- Publication Year :
- 2024
-
Abstract
- Aims and Objectives: To assess the effectiveness of different nonpharmacological treatments for severe radiation‐induced oral mucositis in patients with head and neck cancer. Background: Radiation‐induced oral mucositis is highly prevalent in patients with head and neck cancer. Current medications for radiation‐induced oral mucositis are limited in effectiveness and susceptible to side effects, and while there is an increasing adoption of nonpharmacological interventions, the optimal one remains unclear. Design: Systematic review and network meta‐analysis based on the PRISMA‐NMA guidelines. Methods: Six databases were searched. Two authors independently performed the literature screening, data extraction and methodological quality assessment of the included studies. Traditional pairwise meta‐analysis was performed by R Studio. A network meta‐analysis was then conducted to assess the effects of nonpharmacological interventions for severe radiation‐induced oral mucositis in patients with head and neck cancer. Results: Fifty‐two studies involving seven types of nonpharmacological interventions were enrolled. The network meta‐analysis indicated that natural plant‐based therapies might be the most effective, health education interventions might be the second most effective, and honey might be the third most effective interventions for reducing the incidence of severe radiation‐induced oral mucositis. For reducing the incidence of severe oral mucositis‐related pain, the pairwise meta‐analysis showed that only natural plant‐based therapies and health education interventions were effective. Conclusions: Nonpharmacological interventions are effective in the management of severe radiation‐induced oral mucositis among patients with head and neck cancer. Relevance to clinical practice: Nonpharmacological interventions are a category of safe and effective adjunctive therapies that should be encouraged in clinical practice. Trial registration details: CRD42023400745. [ABSTRACT FROM AUTHOR]
- Subjects :
- PHYTOTHERAPY
THERAPEUTIC use of honey
STOMATITIS treatment
STOMATITIS
MEDICAL information storage & retrieval systems
RESEARCH funding
RADIATION injuries
HEAD & neck cancer
CINAHL database
TREATMENT effectiveness
META-analysis
SYSTEMATIC reviews
MEDLINE
ALTERNATIVE medicine
MEDICAL databases
PAIN management
HEALTH education
PSYCHOLOGY information storage & retrieval systems
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 09621067
- Volume :
- 33
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Nursing (John Wiley & Sons, Inc.)
- Publication Type :
- Academic Journal
- Accession number :
- 176717443
- Full Text :
- https://doi.org/10.1111/jocn.17087