Exploiting c-RAF dependency in RAS mutant cancer: beyond catalytic activity.

This document explores different approaches to targeting c-RAF, a protein involved in the growth of cancer cells with RAS mutations. The authors discuss the limitations of current kinase inhibitors and the need for novel strategies to exploit c-RAF activity. They examine the use of disruptor peptides and small molecule mimetics to inhibit c-RAF and prevent cancer cell growth. The article emphasizes the complexity of the relationship between RAS mutational status and c-RAF dependency and highlights the importance of further research in this area. The authors declare no conflicts of interest and acknowledge the use of the DepMap Portal database for their research. [Extracted from the article]