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Statins, ACE/ARBs drug use, and risk of pneumonia in hospitalized older patients: a retrospective cohort study.

Authors :
Franchi, Carlotta
Rossio, Raffaella
Mandelli, Sara
Ardoino, Ilaria
Nobili, Alessandro
Peyvandi, Flora
Mannucci, Pier Mannuccio
Sesti, Giorgio
Pietrangelo, Antonello
Perticone, Francesco
Violi, Francesco
Corrao, Salvatore
Marengoni, Alessandra
Tettamanti, Mauro
Pasina, Luca
Novella, Alessio
Miglio, Gabriella
Galbussera, Alessia Antonella
Cantiero, Silvia
Prisco, Domenico
Source :
Internal & Emergency Medicine; Apr2024, Vol. 19 Issue 3, p689-696, 8p
Publication Year :
2024

Abstract

The aims of this study is to evaluate the association between angiotensin-converting enzyme inhibitor (ACE-I), angiotensin II receptor blocker (ARBs) and/or statin use with the risk of pneumonia, as well as and with in-hospital and short-term outpatient mortality in hospitalized older patients with pneumonia. Patients aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro Politerapuie SIMI–Società Italiana di Medicina Interna) register from 2010 to 2019 were screened to assess the diagnosis of pneumonia and classified on whether or not they were prescribed with at least one drug among ACE-I, ARBs, and/or statins. Further study outcomes were mortality during hospital stay and at 3 months after hospital discharge. Among 5717 cases included (of whom 18.0% with pneumonia), 2915 (51.0%) were prescribed at least one drug among ACE-I, ARBs, and statins. An inverse association was found between treatment with ACE-I or ARBs and pneumonia (OR = 0.79, 95% CI 0.65–0.95). A higher effect was found among patients treated with ACE-I or ARBs in combination with statins (OR = 0.67, 95% CI 0.52–0.85). This study confirmed in the real-world setting that these largely used medications may reduce the risk of pneumonia in older people, who chronically take them for cardiovascular conditions. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18280447
Volume :
19
Issue :
3
Database :
Complementary Index
Journal :
Internal & Emergency Medicine
Publication Type :
Academic Journal
Accession number :
176781568
Full Text :
https://doi.org/10.1007/s11739-023-03528-w