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Inactivation Mechanisms of Escherichia coli in Simulants of Respiratory and Environmental Aerosol Droplets.

Authors :
Otero-Fernandez, Mara
Thomas, Richard J.
Oswin, Henry
Alexander, Robert
Haddrell, Allen
Reid, Jonathan P.
Source :
Atmosphere; Apr2024, Vol. 15 Issue 4, p511, 21p
Publication Year :
2024

Abstract

The airborne transmission of disease relies on the ability of microbes to survive aerosol transport and, subsequently, cause infection when interacting with a host. The length of time airborne microorganisms remain infectious in aerosol droplets is a function of numerous variables. We present measurements of mass and heat transfer from liquid aerosol droplets combined with airborne survival data for Escherichia coli MRE162, an ACDP category 1 microorganism used as a model system, under a wide range of environmental conditions, droplet compositions and microbiological conditions. In tandem, these companion measurements demonstrate the importance of understanding the complex relationship between aerosol microphysics and microbe survival. Specifically, our data consist of the correlation of a wide range of physicochemical properties (e.g., evaporation rates, equilibrium water content, droplet morphology, compositional changes in droplet solute and gas phase, etc.), with airborne viability decay to infer the impact of aerosol microphysics on airborne bacterial survival. Thus, a mechanistic approach to support prediction of the survival of microorganisms in the aerosol phase as a function of biological, microphysical, environmental, and experimental (aerosol-generation and sampling) processes is presented. Specific findings include the following: surfactants do not increase bacteria stability in aerosol, while both the bacteria growth phase and bacteria concentration may affect the rate at which bacteria decay in aerosol. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20734433
Volume :
15
Issue :
4
Database :
Complementary Index
Journal :
Atmosphere
Publication Type :
Academic Journal
Accession number :
176880422
Full Text :
https://doi.org/10.3390/atmos15040511