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The GPR84 Antagonist GLPG1205 Reduces Features of Disease in Experimental Severe Asthma.

Authors :
Donovan, Chantal
Thorpe, Andrew E.
Gomez, Henry M.
Carroll, Olivia R.
Feng, Min
Bai, Xu
Chen, Hui
Horvat, Jay C.
Oliver, Brian G. G.
Kim, Richard Y.
Source :
American Journal of Respiratory Cell & Molecular Biology; May2024, Vol. 70 Issue 5, p424-427, 4p
Publication Year :
2024

Abstract

The article discusses the potential therapeutic impact of the GPR84 antagonist GLPG1205 in experimental severe asthma. It emphasizes GPR84's role in lung inflammation and metabolism, as well as the compound's effect on reducing airway inflammation and hyperresponsiveness, particularly in neutrophilic inflammation and steroid-insensitive features.

Details

Language :
English
ISSN :
10441549
Volume :
70
Issue :
5
Database :
Complementary Index
Journal :
American Journal of Respiratory Cell & Molecular Biology
Publication Type :
Academic Journal
Accession number :
176929009
Full Text :
https://doi.org/10.1165/rcmb.2023-0221LE