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Survival After Gastric Adenocarcinoma Resection: Eighteen-Year Experience at a Single Institution
- Source :
- Journal of Gastrointestinal Surgery; May2005, Vol. 9 Issue 5, p718-725, 8p
- Publication Year :
- 2005
-
Abstract
- Gastric adenocarcinoma is the second leading cause of cancer death worldwide. In Western series, survival rates vary widely and are generally lower than those reported from Eastern series. We performed a retrospective analysis of cases operated on at the Johns Hopkins Hospital over the past 18 years and collected data on demographics, tumor characteristics, pathologic stage, treatment methods, complications, survival time, and other relevant factors. Survival according to stage of disease, Lauren tumor type, tumor location, time period, and administration of adjuvant therapy was analyzed, and results were compared with those of other Western series. During this period, 436 patients with gastric adenocarcinoma underwent resection. We have shown a statistically significant association between survival and margin status, stage of disease, and Lauren tumor type. Overall 5-year survival was 26%, and 5-year survival after R0 resection was 33%. No significant difference was detected between survival and tumor location, time period of treatment, or administration of adjuvant therapy. Analysis of various Western series reveals major differences between the cohorts under study, such as stage of disease, extent of resection, tumor type, and tumor location. Many of the reported differences among Western series may be due to cohort differences, such as stage of disease, extent of resection, tumor type, and tumor location. [Copyright &y& Elsevier]
- Subjects :
- ADENOCARCINOMA
CANCER treatment complications
TUMORS
DEMOGRAPHY
ADJUVANT treatment of cancer
ACADEMIC medical centers
COMPARATIVE studies
GASTRECTOMY
IMMUNOHISTOCHEMISTRY
LONGITUDINAL method
RESEARCH methodology
MEDICAL cooperation
NEEDLE biopsy
PROBABILITY theory
PROGNOSIS
RESEARCH
RISK assessment
STOMACH tumors
SURVIVAL analysis (Biometry)
TIME
TUMOR classification
EVALUATION research
TREATMENT effectiveness
RETROSPECTIVE studies
Subjects
Details
- Language :
- English
- ISSN :
- 1091255X
- Volume :
- 9
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Gastrointestinal Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 17699012
- Full Text :
- https://doi.org/10.1016/j.gassur.2004.12.002