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Efficacy and safety of direct oral anticoagulants in patients with atrial fibrillation combined with chronic kidney disease: a systematic review and meta-analysis.
- Source :
- Thrombosis Journal; 4/29/2024, Vol. 22 Issue 1, p1-19, 19p
- Publication Year :
- 2024
-
Abstract
- Background: Currently published studies have not observed consistent results on the efficacy and safety of direct oral anticoagulants (DOACs) use in patients with chronic kidney disease (CKD) combined with atrial fibrillation (AF). Therefore, this study conducted a meta-analysis of the efficacy and safety of DOACs for patients with AF complicated with CKD. Methods: Database literature was searched up to May 30, 2023, to include randomized controlled trials (RCT) involving patients with AF complicated with CKD DOACs and vitamin K antagonists (VKAs). Stroke, systemic embolism (SE), and all-cause mortality were used as effectiveness indicators, and major bleeding, intracranial hemorrhage (ICH), fatal bleeding, gastrointestinal bleeding (GIB), and clinically relevant non-major bleeding (CRNMB) were used as safety outcomes. Results: Nine RCT studies were included for analysis according to the inclusion criteria. Results of the efficacy analysis showed that compared with VKAs, DOACs reduced the incidence of stroke/SE (OR = 0.75, 95% CI 0.67–0.84) and all-cause deaths (OR = 0.84, 95% CI 0.75–0.93) in patients with AF who had comorbid CKD. Safety analyses showed that compared with VKAs, DOACs improved safety by reducing the risk of major bleeding (OR = 0.76, 95%CI 0.65–0.90), ICH (OR = 0.46, 95%CI 0.38–0.56), and fatal bleeding (OR = 0.75, 95%CI 0.65–0.87), but did not reduce the incidence of GIB and CRNMB. Conclusion: Compared with VKAs, DOACs may increase efficacy and improve safety in AF patients with CKD (90 ml/min> Crcl≥15 ml/min), and shows at least similar efficacy and safety in AF patients with Kidney failure (Crcl<15 ml/min). [ABSTRACT FROM AUTHOR]
- Subjects :
- HEMORRHAGE risk factors
MORTALITY risk factors
ANTICOAGULANTS
INTRACRANIAL hemorrhage
RISK assessment
PATIENT safety
GASTROINTESTINAL hemorrhage
TREATMENT effectiveness
ORAL drug administration
META-analysis
CHRONIC kidney failure
SYSTEMATIC reviews
MEDLINE
ODDS ratio
ATRIAL fibrillation
ONLINE information services
CONFIDENCE intervals
STROKE
COMORBIDITY
EVALUATION
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 14779560
- Volume :
- 22
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Thrombosis Journal
- Publication Type :
- Academic Journal
- Accession number :
- 176999427
- Full Text :
- https://doi.org/10.1186/s12959-024-00608-5