Researcher at Harvard Medical School Reports Research in Gliomas (Endovascular Applications for the Management of High-Grade Gliomas in the Modern Era).

A recent study conducted by researchers at Harvard Medical School explores the use of endovascular therapies for the treatment of high-grade gliomas (HGGs), a type of brain tumor with a poor prognosis. The study highlights the potential of super-selective intra-arterial cerebral infusion (SSIACI) as a method to deliver anti-tumoral therapies directly to tumor regions while minimizing systemic toxicity. The researchers also discuss challenges such as blood-brain barrier penetration and drug-tumor residence time, and suggest innovative techniques like focused ultrasound and hyperosmotic disruption to enhance drug penetration. The study concludes that while endovascular strategies hold promise in reshaping HGG treatment, further research and validation are needed to translate these advancements into clinical care. [Extracted from the article]