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Comparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study.
- Source :
- BMC Oral Health; 5/3/2024, Vol. 24 Issue 1, p1-7, 7p
- Publication Year :
- 2024
-
Abstract
- Background: This study aimed to assess and compare the concentrations of growth factors, white blood cells (WBCs), and platelets in injectable platelet-rich fibrin (i-PRF) derived from people with healthy periodontal conditions and those with chronic periodontitis. Methods: Venous blood samples were obtained from 30 patients diagnosed with chronic periodontitis (test group) and 30 participants with healthy periodontal conditions (control group). The i-PRF was then acquired from centrifuged blood. The growth factors (VEGF, IGF-1, TGF-β1, PDGF-BB and EGF) released from the i-PRF samples were compared between groups with ELISA testing. The amounts of WBCs and platelets were also compared. Results: No significant differences in the concentrations of growth factors were found between the groups (the mean values for the control and test groups were, respectively: IGF: 38.82, 42.46; PDGF: 414.25, 466.28; VEGF: 375.69, 412.18; TGF-β1: 21.50, 26.21; EGF: 138.62, 154.82). The test group exhibited a significantly higher WBC count than the control group (8.80 vs. 6.60, respectively). However, the platelet count did not show a statistically significant difference between the groups (control group 242.0 vs. test group 262.50). No significant correlation was observed between WBC count and growth factor level in either group. Conclusions: The growth factor levels in i-PRFs did not exhibit significant difference between the two groups. This suggests that the levels of these growth factors may be unaffected by the periodontal disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- PLATELET-rich fibrin
LEUCOCYTES
CROSS-sectional method
VASCULAR endothelial growth factors
LEUKOCYTE count
PLATELET count
RESEARCH funding
SCIENTIFIC observation
PILOT projects
PLATELET-derived growth factor
ENZYME-linked immunosorbent assay
DESCRIPTIVE statistics
CHRONIC diseases
BLOOD platelets
INJECTIONS
EPIDERMAL growth factor
GROWTH factors
CASE-control method
SOMATOMEDIN
PERIODONTITIS
TRANSFORMING growth factors-beta
Subjects
Details
- Language :
- English
- ISSN :
- 14726831
- Volume :
- 24
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Oral Health
- Publication Type :
- Academic Journal
- Accession number :
- 177044736
- Full Text :
- https://doi.org/10.1186/s12903-024-04301-x