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Using Polygenic Risk Scores to Aid Diagnosis of Patients With Early Inflammatory Arthritis: Results From the Norfolk Arthritis Register.
- Source :
- Arthritis & Rheumatology; May2024, Vol. 76 Issue 5, p696-703, 8p
- Publication Year :
- 2024
-
Abstract
- Objective: There is growing evidence that genetic data are of benefit in the rheumatology outpatient setting by aiding early diagnosis. A genetic probability tool (G‐PROB) has been developed to aid diagnosis has not yet been tested in a real‐world setting. Our aim was to assess whether G‐PROB could aid diagnosis in the rheumatology outpatient setting using data from the Norfolk Arthritis Register (NOAR), a prospective observational cohort of patients presenting with early inflammatory arthritis. Methods: Genotypes and clinician diagnoses were obtained from patients from NOAR. Six G‐probabilities (0%–100%) were created for each patient based on known disease‐associated odds ratios of published genetic risk variants, each corresponding to one disease of rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, spondyloarthropathy, gout, or "other diseases." Performance of the G‐probabilities compared with clinician diagnosis was assessed. Results: We tested G‐PROB on 1,047 patients. Calibration of G‐probabilities with clinician diagnosis was high, with regression coefficients of 1.047, where 1.00 is ideal. G‐probabilities discriminated clinician diagnosis with pooled areas under the curve (95% confidence interval) of 0.85 (0.84–0.86). G‐probabilities <5% corresponded to a negative predictive value of 96.0%, for which it was possible to suggest >2 unlikely diseases for 94% of patients and >3 for 53.7% of patients. G‐probabilities >50% corresponded to a positive predictive value of 70.4%. In 55.7% of patients, the disease with the highest G‐probability corresponded to clinician diagnosis. Conclusion: G‐PROB converts complex genetic information into meaningful and interpretable conditional probabilities, which may be especially helpful at eliminating unlikely diagnoses in the rheumatology outpatient setting. [ABSTRACT FROM AUTHOR]
- Subjects :
- RHEUMATOID arthritis diagnosis
RHEUMATOID arthritis risk factors
GENETICS of rheumatoid arthritis
RISK assessment
OUTPATIENT services in hospitals
PSORIATIC arthritis
SCIENTIFIC observation
PROBABILITY theory
RESEARCH methodology evaluation
REPORTING of diseases
SYSTEMIC lupus erythematosus
DESCRIPTIVE statistics
GENEALOGY
GENETIC risk score
EXPERIMENTAL design
LONGITUDINAL method
ODDS ratio
RESEARCH methodology
GOUT
EARLY diagnosis
INFLAMMATION
COMPARATIVE studies
CALIBRATION
CONFIDENCE intervals
GENETIC techniques
GENOTYPES
REGRESSION analysis
PREDICTIVE validity
Subjects
Details
- Language :
- English
- ISSN :
- 23265191
- Volume :
- 76
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Arthritis & Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 177083583
- Full Text :
- https://doi.org/10.1002/art.42760