Back to Search Start Over

Trial of Cardiovascular Risk Factor Assessment and Transthoracic Echocardiography Results in Patients with Primary Antibody Deficiency.

Authors :
Napiórkowska-Baran, Katarzyna
Grześk, Grzegorz
Błażejewski, Jan
Ziętkiewicz, Marcin
Więsik-Szewczyk, Ewa
Matyja-Bednarczyk, Aleksandra
Tykwińska, Marta
Grześk, Elżbieta
Lubański, Jakub
Schmidt, Oskar
Szymczak, Bartłomiej
Zacniewski, Robert
Szynkiewicz, Ewa
Owsiany, Michał
Bartuzi, Zbigniew
Source :
Iranian Journal of Allergy, Asthma & Immunology; Apr2024, Vol. 23 Issue 2, p168-181, 14p
Publication Year :
2024

Abstract

The life expectancy and the risk of developing cardiovascular diseases in patients with inborn errors of immunity are systematically increasing. The aim of the study was to assess cardiovascular risk factors and to evaluate the heart in echocardiography in patients with primary antibody deficiency (PAD). Cardiac echography and selected cardiovascular risk factors, including body mass index, sedentary lifestyle, nicotine, glucose, C-reactive protein, lipid profile, uric acid level, certain chronic diseases, and glucocorticoid use, were analyzed in 94 patients >18 years of age with PAD. Of the patients,25.5% had a cardiovascular disease (mostly hypertension, 18%), 10.5% smoked, 17% were overweight, 14% were obese, and 15% were underweight. Abnormal blood pressure was found in 6.5% of the patients. Lipid metabolism disorders were found in 72.5% of in the studied cohort, increased total cholesterol (45.5%), non-high-density lipoprotein (HDL) (51%), low-density lipoprotein (LDL) (47%), and triglycerides (32%) were observed. Furthermore, 28.5% had a decrease in HDL and 9.5% had a history of hyperuricemia. The average number of risk factors was 5 ± 3 for the entire population and 4 ± 2 for those under 40 years of age. Elevated uric acid levels were found de novo in 4% of participants. In particular, 74.5% of the patients had never undergone an echocardiogram with a successful completion rate of 87% among those tested. Among them, 30% showed parameters within normal limits, primarily regurgitation (92.5%). New pathologies were identified in 28% of patients. Prevention in patients with PAD, aimed at reducing cardiovascular risk, should be a priority [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17351502
Volume :
23
Issue :
2
Database :
Complementary Index
Journal :
Iranian Journal of Allergy, Asthma & Immunology
Publication Type :
Academic Journal
Accession number :
177093106
Full Text :
https://doi.org/10.18502/ijaai.v23i2.15323