Back to Search Start Over

Dapagliflozin Reduces Urinary Kidney Injury Biomarkers in Chronic Kidney Disease Irrespective of Albuminuria Level.

Authors :
Cho, Junghyun
Doo, Seung Whan
Song, Nayoung
Lee, Minsul
Lee, Haekyung
Kim, Hyongnae
Jeon, Jin Seok
Noh, Hyunjin
Kwon, Soon Hyo
Source :
Clinical Pharmacology & Therapeutics; Jun2024, Vol. 115 Issue 6, p1441-1449, 9p
Publication Year :
2024

Abstract

The beneficial effects of sodium–glucose cotransporter 2 (SGLT2) inhibitors in patients with chronic kidney disease (CKD) with low albuminuria levels have not been established. This study aimed to compare the effects of dapagliflozin on kidney injury biomarkers in patients with CKD stratified by albuminuria level. We prospectively enrolled healthy volunteers (HVs; n = 20) and patients with CKD (n = 54) with and without diabetes mellitus. Patients with CKD were divided into two age‐matched and sex‐matched subgroups according to urinary albumin–creatinine ratio (uACR) levels (<300 mg/g and ≥300 mg/g). The CKD group received dapagliflozin (10 mg/day). Urine samples were collected before treatment and after 3 and 6 months of dapagliflozin. Urinary kidney injury molecule‐1 (KIM‐1), interleukin‐1β (IL‐1β), and mitochondrial DNA nicotinamide adenine dinucleotide dehydrogenase subunit‐1 (mtND1) copy number were measured. The estimated glomerular filtration rate (eGFR) of patients with CKD was lower than that of HVs (P < 0.001). During the study period, eGFR decreased and uACR did not change in the CKD group. Kidney injury markers were significantly elevated in patients with CKD compared with those in HVs. Dapagliflozin reduced urinary KIM‐1, IL‐1β, and mtDNA copy number in patients with CKD after 6 months of treatment. In further, the levels of urinary KIM‐1 and IL‐1β, patients with CKD decreased after 6 months of dapagliflozin treatment regardless of albuminuria level. Dapagliflozin reduced urinary kidney injury biomarkers in patients with CKD, regardless of albuminuria level. These findings suggest that SGLT2 inhibitors may also attenuate the progression of low albuminuric CKD. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00099236
Volume :
115
Issue :
6
Database :
Complementary Index
Journal :
Clinical Pharmacology & Therapeutics
Publication Type :
Academic Journal
Accession number :
177193176
Full Text :
https://doi.org/10.1002/cpt.3237