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Phytochemical study of Magonia pubescens A. St.-Hil. and cytotoxicity of branches aqueous extract on breast cancer and leukemia cells.

Authors :
Moraes, Acácio R. A.
Siqueira, Ezequias P.
Kohlhoff, Markus
Evangelista, Fernanda C. G.
Sabino, Adriano P.
Vieira Filho, Sidney A.
Alcântara, Antônio F. C.
Duarte, Lucienir P.
Sousa, Grasiely F.
Source :
Natural Product Research; Jun2024, Vol. 38 Issue 11, p1956-1960, 5p
Publication Year :
2024

Abstract

Magonia pubescens is a natural species from the Brazilian cerrado biome. Its fruits and seeds are used in the treatment of seborrheic dermatitis, a common inflammatory skin disease. In this work, the known compounds lapachol, stigmasterol, maniladiol and scopoletin were isolated from hexane and dichloromethane extracts of M. pubescens branches. The aqueous extract of this material was fractioned through a liquid-liquid partition and the obtained fractions were analyzed by UHPLC-MS/MS. The results obtained were compared with data from three databases, leading to the putative identification of 51 compounds from different classes, including flavonoids, saponins and triterpenes. The cytotoxicity of aqueous fractions was assayed against breast cancer (MDA-MB-231) and leukemia (THP-1 and K562) cells. The best activity was observed for fraction AE3 against MDA-MB-231 cells (IC<subscript>50</subscript> 30.72 µg.mL<superscript>−1</superscript>). [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14786419
Volume :
38
Issue :
11
Database :
Complementary Index
Journal :
Natural Product Research
Publication Type :
Academic Journal
Accession number :
177218849
Full Text :
https://doi.org/10.1080/14786419.2023.2227988