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Hydroxymethylation hydroxylation of 1,3-diarylpropene through a catalytic diastereoselective Prins reaction: cyclization logic and access to brazilin core.
- Source :
- Natural Products & Bioprospecting; 5/14/2024, Vol. 14 Issue 1, p1-16, 16p
- Publication Year :
- 2024
-
Abstract
- A catalytic diastereoselective Prins reaction for hydroxymethylation and hydroxylation of 1,3-diarylpropene was successfully utilized to prepare various 1,3-dioxanes 7 in 14–88% yields. Take advantage of the synthetic intermediate 7h, the key B/C rings in brazilin core could be constructed by the sequential of Friedel–Crafts/Ullmann-Ma rather than Ullmann-Ma/Friedel–Crafts reactions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 21922209
- Volume :
- 14
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Natural Products & Bioprospecting
- Publication Type :
- Academic Journal
- Accession number :
- 177220429
- Full Text :
- https://doi.org/10.1007/s13659-024-00450-2