Back to Search
Start Over
A Novel Route towards Bicyclo[1.1.1]pentane Sulfoxides from a Bench-Stable Starting Material.
- Source :
- Synlett; Jun2024, Vol. 35 Issue 9, p1023-1027, 5p
- Publication Year :
- 2024
-
Abstract
- This article explores the use of bicyclopentane (BCP) as a bioisostere in medicinal chemistry. BCP can replace phenyl rings or alkynes in molecules, altering their physical properties. The authors focus on the synthesis of BCP-sulfoxides, which can enhance the pharmacological properties of compounds. They present a new method using a BCP-sulfinate precursor that is more convenient and stable. The authors successfully synthesized a previously inaccessible methyl-substituted sulfoxide and suggest the potential for further modifications. [Extracted from the article]
- Subjects :
- PENTANE
SULFOXIDES
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 35
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 177222727
- Full Text :
- https://doi.org/10.1055/a-2210-0893