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Exploring mitochondrial targeting: an innovative fluorescent probe reveals Nernstian potential and partitioning combination.
- Source :
- Chemical Communications; 5/11/2024, Vol. 60 Issue 38, p5062-5065, 4p
- Publication Year :
- 2024
-
Abstract
- This study introduces a paradigm-shifting approach to optimize mitochondrial targeting. Employing a new fluorescent probe strategy, we unravel a combined influence of both Nernst potential (ψ) and partitioning (P) contributions. Through the synthesis of new benz[e]indolinium-derived probes, our findings redefine the landscape of mitochondrial localization by optimizing the efficacy of mitochondrial probe retention in primary cortical neurons undergoing normoxia and oxygen--glucose deprivation. This methodology not only advances our understanding of subcellular dynamics, but also holds promise for transformative applications in biomedical research and therapeutic development. [ABSTRACT FROM AUTHOR]
- Subjects :
- FLUORESCENT probes
MITOCHONDRIA
MEDICAL research
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 60
- Issue :
- 38
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 177263273
- Full Text :
- https://doi.org/10.1039/d4cc01144a