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Genome-wide detections for runs of homozygosity and selective signatures reveal novel candidate genes under domestication in chickens.

Authors :
Tan, Xiaodong
Liu, Lu
Dong, Jie
Huang, Minjie
Zhang, Jiawen
Li, Qinghai
Wang, Huanhuan
Bai, Lijuan
Cui, Ming
Zhou, Zhenzhen
Wu, De
Xiang, Yun
Li, Weifen
Wang, Deqian
Source :
BMC Genomics; 5/16/2024, Vol. 25 Issue 1, p1-14, 14p
Publication Year :
2024

Abstract

Background: Indigenous chickens were developed through a combination of natural and artificial selection; essentially, changes in genomes led to the formation of these modern breeds via admixture events. However, their confusing genetic backgrounds include a genomic footprint regulating complex traits, which is not conducive to modern animal breeding. Results: To better evaluate the candidate regions under domestication in indigenous chickens, we considered both runs of homozygosity (ROHs) and selective signatures in 13 indigenous chickens. The genomes of Silkie feather chickens presented the highest heterozygosity, whereas the highest inbreeding status and ROH number were found in Luhua chickens. Short ROH (< 1 Mb), were the principal type in all chickens. A total of 291 ROH islands were detected, and QTLdb mapping results indicated that body weight and carcass traits were the most important traits. An ROH on chromosome 2 covering VSTM2A gene was detected in 12 populations. Combined analysis with the Tajima's D index revealed that 18 genes (e.g., VSTM2A, BBOX1, and RYR2) were under selection and covered by ROH islands. Transcriptional analysis results showed that RYR2 and BBOX1 were specifically expressed in the heart and muscle tissue, respectively. Conclusion: Based on genome-wide scanning for ROH and selective signatures, we evaluated the genomic characteristics and detected significant candidate genes covered by ROH islands and selective signatures. The findings in this study facilitated the understanding of genetic diversity and provided valuable insights for chicken breeding and conservation strategies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14712164
Volume :
25
Issue :
1
Database :
Complementary Index
Journal :
BMC Genomics
Publication Type :
Academic Journal
Accession number :
177280468
Full Text :
https://doi.org/10.1186/s12864-024-10349-4