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Advantages and disadvantages of using Rho kinase inhibitors to reduce intraocular pressure.
- Source :
- Expert Review of Ophthalmology; Jun2024, Vol. 19 Issue 3, p201-209, 9p
- Publication Year :
- 2024
-
Abstract
- Rho kinase (ROCK) inhibitors (RKIs) have been available commercially as topical ocular hypotensive agents for approximately a decade. RKIs have promise as their presumed mechanism of action is increased trabecular meshwork (TM) outflow, the presumed primary site of pathology in open-angle glaucoma. We reviewed recent literature on netarsudil, ripasudil, H-1337, and VVN539 as monotherapy and in combination with other topical ocular hypotensive agents. With a unique primary mechanism of increase in trabecular outflow, these agents target the glaucomatous pathology in aqueous humor dynamics. The ocular hypotensive efficacy of netarsudil, once-daily (q.d.), is in the range of non-cardioselective beta-adrenoceptor antagonists. Ripasudil, given twice-daily (b.i.d.), is somewhat less effective. H-1337 and VVN539, at an early development stage, both seem to have efficacy in the range of netarsudil. Conjunctival hyperemia is an adverse event common to all RKIs tested to date. The greater adoption of RKIs in therapy may be limited by financial considerations, at least in the U.S. We searched PubMed for the keywords netarsudil (AR13324), ripasudil (K-115), H-1337, and VVN539 as of November 2023. We found 349 citations which we reviewed for consideration in this review. Herein we summarize primary research reports, excluding news stories or meeting abstracts. We also searched to find new trials of interest. [ABSTRACT FROM AUTHOR]
- Subjects :
- PROTEIN kinase inhibitors
CUTANEOUS therapeutics
COMBINATION drug therapy
OCULAR hypertension
GLAUCOMA
INVESTIGATIONAL drugs
ANTIHYPERTENSIVE agents
DRUG efficacy
BETA adrenoceptors
CONJUNCTIVA
HYPEREMIA
PHOSPHOTRANSFERASES
ANTERIOR eye segment
DRUG dosage
PHARMACODYNAMICS
DRUG administration
CHEMICAL inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 17469899
- Volume :
- 19
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Expert Review of Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 177394906
- Full Text :
- https://doi.org/10.1080/17469899.2024.2311669