Back to Search Start Over

Conversion surgery for stage IV gastric cancer with multiple liver metastases with a complete pathological response to S-1 plus oxaliplatin therapy.

Authors :
Sakoh, Teruki
Eto, Kojiro
Iwagami, Shiro
Yoshida, Naoya
Kosumi, Keisuke
Iwatsuki, Masaaki
Baba, Yoshifumi
Miyamoto, Yuji
Yoshii, Daiki
Baba, Hideo
Source :
Clinical Journal of Gastroenterology; Jun2024, Vol. 17 Issue 3, p419-424, 6p
Publication Year :
2024

Abstract

Although patients with stage IV gastric cancer who respond well to systemic chemotherapy can be treated with gastrectomy, the prognosis of patients with multiple liver metastases is poor. We herein describe a patient with stage IV gastric cancer with multiple liver metastases who underwent conversion surgery after systemic treatment with S-1 plus oxaliplatin. The patient was a 62-year-old man. Upper gastrointestinal endoscopy revealed a 30-mm type 2 tumor in the greater curvature of the stomach at the anterior wall, and biopsy revealed a poorly differentiated adenocarcinoma. Imaging showed three suspected liver metastases in liver segment S8. The patient was judged to have gastric cancer, cStage IV (cT3N1M1(H)), and systemic chemotherapy was administered. He was treated with a total of six courses of chemotherapy. After re-evaluation, the primary tumor had shrunk significantly, and liver metastases could not be detected. Confirming no signs of seeding by laparoscopy, robot-assisted pylorus-preserving gastrectomy with D2 dissection and laparoscopic partial hepatic (S8) resection were performed. The patient was diagnosed with a complete pathological response. Conversion surgery is an option for stage IV gastric cancer when distant metastases are controlled with chemotherapy and when R0 resection is possible. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18657257
Volume :
17
Issue :
3
Database :
Complementary Index
Journal :
Clinical Journal of Gastroenterology
Publication Type :
Academic Journal
Accession number :
177462772
Full Text :
https://doi.org/10.1007/s12328-024-01933-y