Methyl-Containing Pharmaceuticals.

This document is a summary of a special issue of the journal Pharmaceuticals, which focuses on methyl-containing pharmaceuticals. The issue includes various papers and reviews on this topic. The "magic-methyl effect" is a well-known phenomenon in medicinal chemistry and drug discovery, which has implications for biological activity, selectivity, solubility, and other properties. The issue covers different aspects related to the methyl effect, including the anticancer activity of a methyl-containing selenylated imidazo[1,2-a]-pyridine derivative, the synthesis of novel bis-terephthalthioamides, a computational method for predicting the binding mode of COX inhibitors, and the synthesis of mono-methyl tyrosine. The issue also includes a review that analyzes the relationship between chemical structures and biological activity. [Extracted from the article]