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Nickel-Catalyzed Hydroalkynylation of 1,3-Dienes with Simple Alkynes.
- Source :
- Synlett; Jun2024, Vol. 35 Issue 10, p1160-1164, 5p
- Publication Year :
- 2024
-
Abstract
- This article discusses the development of a nickel-catalyzed hydroalkynylation reaction of 1,3-dienes with simple alkynes. The researchers used a Xantphos ligand to achieve regioselective hydroalkynylation, producing a variety of allylic alkyne products. They optimized the reaction conditions by adding water, which increased the yield of the desired product. The method demonstrated excellent functional-group tolerance and a wide substrate scope for alkynes. The researchers also proposed a mechanism for the reaction based on previous studies. Further research will focus on asymmetric variants, expanding the reaction scope, and exploring synthetic applications. [Extracted from the article]
- Subjects :
- ALKYNES
DIELS-Alder reaction
SILYL ethers
VINYL ethers
METHYL groups
ETHYNYL benzene
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 35
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 177517320
- Full Text :
- https://doi.org/10.1055/s-0043-1763605