Nickel-Catalyzed Hydroalkynylation of 1,3-Dienes with Simple Alkynes.

This article discusses the development of a nickel-catalyzed hydroalkynylation reaction of 1,3-dienes with simple alkynes. The researchers used a Xantphos ligand to achieve regioselective hydroalkynylation, producing a variety of allylic alkyne products. They optimized the reaction conditions by adding water, which increased the yield of the desired product. The method demonstrated excellent functional-group tolerance and a wide substrate scope for alkynes. The researchers also proposed a mechanism for the reaction based on previous studies. Further research will focus on asymmetric variants, expanding the reaction scope, and exploring synthetic applications. [Extracted from the article]