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Mediating Effect of White Blood Cells and Tobacco Exposure on Cervical Neoplasm Risk Among Taiwanese Women.
- Source :
- Biological Research for Nursing; Jul2024, Vol. 26 Issue 3, p380-389, 10p
- Publication Year :
- 2024
-
Abstract
- Background: Both the high-risk human papillomavirus (HR-HPV) infection and tobacco exposure are significantly associated with cervical neoplasm risk. Immune cells play important roles in carcinogenesis. However, it is still unclear whether immune cells have a mediating effect on the HR-HPV infection and tobacco exposure with cervical neoplasm development. Aim: The aim of this study was to determine how the increased white blood cell (WBC) count affects the relationship between HR-HPV DNA load and tobacco exposure in the development of cervical neoplasia. Methods: A hospital-based case–control study design was conducted with a total of 108 cases of Taiwanese women with ≥ cervical intraepithelial neoplasia (CIN) I confirmed by biopsy, and 222 healthy Taiwanese female subjects with negative findings on a Pap smear were assigned to the control group. The study evaluated HR-HPV status and immune cell counts (WBCs, natural killer (NK) cells) and tobacco exposure by a self-construct questionnaire. Results: Both HR-HPV DNA load and tobacco exposure significantly independently increased cervical neoplasm risk (AORs: 1.28 and 1.42, respectively). Similar significant results were found for WBCs and NK cells, with respective AORs of 1.20 and 1.00. Moreover, increased WBCs (β = 0.04, 95% CI corrected: 0.01–0.07) and tobacco exposure (β = 0.02, 95% CI corrected: 0.01–0.04) mediated the relationship between the high-risk HPV DNA load and cervical neoplasm risk. Conclusions: Elevated WBC count acts as both predictor and mediator in cervical neoplasm development linked to HR-HPV DNA load. Monitoring and maintaining WBC levels within the normal range could be a preventive strategy for cervical neoplasm development. [ABSTRACT FROM AUTHOR]
- Subjects :
- LEUKOCYTE count
RISK assessment
TAIWANESE people
CERVICAL intraepithelial neoplasia
BIOPSY
CERVIX uteri tumors
WOMEN
VIRAL load
KILLER cells
T-test (Statistics)
RESEARCH funding
SMOKING
QUESTIONNAIRES
LOGISTIC regression analysis
MULTIPLE regression analysis
INTERVIEWING
DNA
PAPILLOMAVIRUSES
DESCRIPTIVE statistics
RETROSPECTIVE studies
CHI-squared test
ODDS ratio
CASE-control method
PAP test
CONFIDENCE intervals
DATA analysis software
FACTOR analysis
PASSIVE smoking
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 10998004
- Volume :
- 26
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Biological Research for Nursing
- Publication Type :
- Academic Journal
- Accession number :
- 177518505
- Full Text :
- https://doi.org/10.1177/10998004241229069