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Design, synthesis and performance test of a hydrogen peroxide fluorescent probe based on selenomorpholine and pyrimidine.
- Source :
- International Journal of Environmental Analytical Chemistry; Jul2024, Vol. 104 Issue 8, p1765-1777, 13p
- Publication Year :
- 2024
-
Abstract
- As a vital biological molecule, H<subscript>2</subscript>O<subscript>2</subscript>(Hydrogen Peroxide) is involved in different physiological and pathological processes. And in addition to this, H<subscript>2</subscript>O<subscript>2</subscript> is suitable for medical wound disinfection, environmental disinfection and food disinfection. Accordingly, it is of high significance to conveniently and effectively detect H<subscript>2</subscript>O<subscript>2</subscript> in the environment and organisms. This subject synthesised a fluorescent probe Pyrimidine-Se by using selenomorpholine and pyrimidine dye, which detect H<subscript>2</subscript>O<subscript>2</subscript> in an aqueous environment. Pyrimidine-Se has a large Stokes shift (Δλ = 155 nm), which can specifically and quickly quantitatively detect H<subscript>2</subscript>O<subscript>2</subscript>. When the probe Pyrimidine-Se reacted with H<subscript>2</subscript>O<subscript>2</subscript>, the Se(II) in the selenomorpholine was oxidised to Se(IV), so the electron withdrawing ability of the electron withdrawing group of Pyrimidine-Se was improved, and the fluorescence intensity of the probe were enhanced. Interestingly, Se(IV) can be reduced by GSH (Glutathione) to Se(II) to quench the fluorescence, and this redox cycle can continue several times, which indicated that it can have a potential of real-time monitoring the redox state in vivo. The probe was also satisfactorily used to detect H<subscript>2</subscript>O<subscript>2</subscript> in Argentina Bloodfin larvaes and abnormal H<subscript>2</subscript>O<subscript>2</subscript> content in some organs was detected. [ABSTRACT FROM AUTHOR]
- Subjects :
- FLUORESCENT probes
HYDROGEN peroxide
MORPHOLINE
PYRIMIDINES
BIOMOLECULES
STOKES shift
Subjects
Details
- Language :
- English
- ISSN :
- 03067319
- Volume :
- 104
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- International Journal of Environmental Analytical Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 177520280
- Full Text :
- https://doi.org/10.1080/03067319.2022.2047183