Study Results from Chinese Academy of Sciences Provide New Insights into Nanoparticles (Curvature-mediated rapid extravasation and penetration of nanoparticles against interstitial fluid pressure for improved drug delivery).

A recent study conducted by the Chinese Academy of Sciences has explored the use of nanoparticles for improved drug delivery. The researchers focused on the challenge of elevated interstitial fluid pressure (IFP) within pathological tissues, which hinders the transport of nanomedicine and reduces therapeutic efficiency. The study proposes a solution by engineering nanoparticles with a fusiform shape of high curvature, which enables them to overcome IFP barriers during extravasation and penetration within tumor tissues. The research demonstrates that these elongated nanoparticles outperform spherical and rod-shaped counterparts, leading to superior intratumoral accumulation and antitumor efficacy. This study provides valuable insights into the physical properties of nanoparticles and their interactions with the environment, offering a promising avenue for advancing cancer treatment through nanomedicine. [Extracted from the article]