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The value of fibrinogen combined with D-dimer and neonatal weight in predicting postpartum hemorrhage in vaginal delivery.
- Source :
- Journal of Perinatal Medicine; Jun2024, Vol. 52 Issue 5, p478-484, 7p
- Publication Year :
- 2024
-
Abstract
- The purpose of this study was to explore whether fibrinogen (Fib) can be used as a predictor of postpartum hemorrhage (PPH) in parturients with vaginal delivery, and the value of combining Fib with other indexes to predict postpartum hemorrhage in vaginal delivery. A total of 207 parturients who delivered via vagina were divided into PPH group (n=102) and non-PPH group (n=105). The PPH group was further divided into mild PPH group and severe PPH group. The differences of Fib, platelet (PLT), mean platelet volume (MPV), platelet distribution width (PDW), D-dimer (D-D), hemoglobin (HGB) and neonatal weight (Nw) between the two groups were compared to explore the significance of these indexes in predicting PPH. Fib, PLT and PDW in PPH group were significantly lower than those in non-PPH group, while D-D and Nw in PPH group were significantly higher than those in non-PPH group. In the binary logistic regression model, we found that Fib, D-D and Nw were independently related to PPH. The risk of PPH increased by 9.87 times for every 1 g/L decrease in Fib. The cut-off value of Fib is 4.395 (sensitivity 0.705, specificity 0.922). The AUC value of PPH predicted by Fib combined with D-D and Nw was significantly higher than that of PPH predicted by Fib (p<0.05, 95 % CI 0.00313–0.0587). Fib, D-D and Nw have good predictive value for PPH of vaginal delivery, among which Fib is the best. The combination of three indexes of Fib, D-D and Nw can predict PPH more systematically and comprehensively, and provide a basis for clinical prevention and treatment of PPH. [ABSTRACT FROM AUTHOR]
- Subjects :
- PREDICTIVE tests
RISK assessment
PREDICTION models
DELIVERY (Obstetrics)
VAGINA
MATERNAL health services
T-test (Statistics)
RECEIVER operating characteristic curves
BLOOD collection
LOGISTIC regression analysis
FIBRIN fibrinogen degradation products
POSTPARTUM hemorrhage
RETROSPECTIVE studies
DESCRIPTIVE statistics
MANN Whitney U Test
CHI-squared test
PREGNANT women
FIBRINOGEN
MEDICAL records
ACQUISITION of data
CASE-control method
STATISTICS
BIRTH weight
BLOOD coagulation
DATA analysis software
CONFIDENCE intervals
MILITARY hospitals
SENSITIVITY & specificity (Statistics)
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 03005577
- Volume :
- 52
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Perinatal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 177601997
- Full Text :
- https://doi.org/10.1515/jpm-2023-0351