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Simultaneous Screening of 172 Veterinary Drugs by Modified QuEChERS-LC–MS/MS in TCM Galli Gigerii Endothelium Corneum.
- Source :
- Journal of Chromatographic Science; May/Jun2024, Vol. 62 Issue 5, p439-443, 5p
- Publication Year :
- 2024
-
Abstract
- An analytical method was developed for the screening of 172 veterinary drugs in traditional Chinese medicine Galli Gigerii Endothelium Corneum by high-performance liquid chromatography tandem mass spectrometry. The samples were pretreated by a modified QuEChERS method. A Zorbax Eclipse plus C18 column (1.8 μm, 3.0 × 150 mm<superscript>2</superscript>, Agilent) was used for the separation of analytes by gradient elution. All analytes were detected by electrospray ionization mass spectrometry with multiple reaction monitoring mode. Good linearity with R ≥ 0.99 was exhibited for all analytes within the respective range. The recoveries of all monitored analytes ranged from 55.4 to 127.6% at three spiked levels (limit of quantitation—LOQ, 2-fold LOQ, 10-fold LOQ), with relative standard deviations <17.8%. The estimated LOQ levels were 0.2–20 μg/kg. The application of this method provides a reference for the safety control of traditional Chinese medicines. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00219665
- Volume :
- 62
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Chromatographic Science
- Publication Type :
- Academic Journal
- Accession number :
- 177611362
- Full Text :
- https://doi.org/10.1093/chromsci/bmae014