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MRTF‐A/SRF signaling suppresses invasion of oral squamous cell carcinoma.
- Source :
- Oral Diseases; May2024, Vol. 30 Issue 4, p1919-1934, 16p
- Publication Year :
- 2024
-
Abstract
- Background: Serum response factor (SRF) and myocardial‐associated transcription factor‐A (MRTF‐A) had different regulatory effects on the tumorigenesis and development in different cancers. However, the role of MRTF‐A/SRF in oral squamous cell carcinoma (OSCC) remains to be determined. Methods: CCK‐8 assay, cell scratch experiment, and transwell invasion assay were conducted to investigate the effects of MRTF‐A/SRF on biological behavior of OSCC cells. The expression pattern and prognostic value of MRTF‐A/SRF in OSCC were analyzed based on cBioPortal website and TCGA database. Protein–protein interaction network was visualized to identify protein functions. Go and KEGG pathway analyses were performed to investigate related pathways. The effect of MRTF‐A/SRF on epithelial–mesenchymal transformation (EMT) of OSCC cells was explored by western blot assay. Results: Overexpression of MRTF‐A/SRF inhibited the proliferation, migration, and invasion of OSCC cells in vitro. High expression of SRF was related to better prognosis of OSCC patients on hard palate, alveolar ridge, and oral tongue. Besides, overexpression of MRTF‐A/SRF inhibited the EMT of OSCC cells. Conclusion: SRF was closely related to the prognosis of OSCC. High expression of SRF and its co‐activator MRTF‐A inhibited proliferation, migration, and invasion of OSCC cells in vitro, possibly via EMT suppression. [ABSTRACT FROM AUTHOR]
- Subjects :
- SQUAMOUS cell carcinoma
WORLD Wide Web
PROTEINS
IN vitro studies
MOUTH tumors
RESEARCH funding
COLORIMETRY
EPITHELIAL-mesenchymal transition
GENOMICS
PALATE
CELL proliferation
CELLULAR signal transduction
TRANSCRIPTION factors
CELL motility
CELL lines
TONGUE
WESTERN immunoblotting
ALVEOLAR process
Subjects
Details
- Language :
- English
- ISSN :
- 1354523X
- Volume :
- 30
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Oral Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 177613918
- Full Text :
- https://doi.org/10.1111/odi.14611