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Ameliorative effect of Ganoderma lucidum on sodium arsenite induced toxicity in Charles Foster rats.

Authors :
Sinha, Mukesh Kumar
Kumari, Rekha
Kumar, Arun
Source :
Journal of Advanced Zoology; 2024, Vol. 45 Issue 5, p57-70, 14p
Publication Year :
2024

Abstract

Groundwater contamination in India exposes an estimated 70 million people to arsenic. Over 10 million people in the state of Bihar (India) are at risk of arsenic poisoning. As reported 27 districts of the state's thirty-eight districts are under a state of catastrophe. Symptoms noticed by those who have been exposed to the arsenic caused disease are-lack of appetite, neurobehavioral problems, hyperkeratosis, and melanosis on the skin. So, this study's primary objective is to find novel approaches to treat arsenic poisoning in rats using the Charles Foster model. Following permission from the Institutional Animal Ethics Committee, the animals were divided into three groups: one group served as a control, the second group received arsenic treatment, and the third group received Ganoderma lucidum extract after arsenic treatment. For the arsenic group, the rats were given 8 mg/kg body weight of sodium arsenite orally every day for 90 days, and then for 60 days, they were given 80 mg/Kg body weight of Ganoderma lucidum extract via gavage. Their biochemical values, including those of the liver and kidneys, were found to be increased. In addition, their levels of free radicals, including lipid peroxidation, were measured and found to be substantially higher. In addition, the levels of arsenic in the kidney and liver tissue were very high. However, biochemical and lipid peroxidation levels were significantly restored after administration of Ganoderma lucidum ethanolic extract. Arsenic levels in rat liver and kidney tissues were also found to be reduced. Ganoderma lucidum has a therapeutic impact against arsenicinduced toxicity, according to the present research. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02537214
Volume :
45
Issue :
5
Database :
Complementary Index
Journal :
Journal of Advanced Zoology
Publication Type :
Academic Journal
Accession number :
177768591
Full Text :
https://doi.org/10.53555/jaz.v45i5.4704