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Floating electrode–dielectric barrier discharge-based plasma promotes skin regeneration in a full-thickness skin defect mouse model.
- Source :
- Biomedical Engineering Letters; May2024, Vol. 14 Issue 3, p605-616, 12p
- Publication Year :
- 2024
-
Abstract
- Wound healing involves a complex and dynamic interplay among various cell types, cytokines, and growth factors. Macrophages and transforming growth factor-β1 (TGF-β1) play an essential role in different phases of wound healing. Cold atmospheric plasma has a wide range of applications in the treatment of chronic wounds. Hence, we aimed to investigate the safety and efficacy of a custom-made plasma device in a full-thickness skin defect mouse model. Here, we investigated the wound tissue on days 6 and 12 using histology, qPCR, and western blotting. During the inflammation phase of wound repair, macrophages play an important role in the onset and resolution of inflammation, showing decreased F4/80 on day 6 of plasma treatment and increased TGF-β1 levels. The plasma-treated group showed better epidermal epithelialization, dermal fibrosis, collagen maturation, and reduced inflammation than the control group. Our findings revealed that floating electrode-dielectric barrier discharge (FE-DBD)-based atmospheric-pressure plasma promoted significantly faster wound healing in the plasma-treated group than that in the control group with untreated wounds. Hence, plasma treatment accelerated wound healing processes without noticeable side effects and suppressed pro-inflammatory genes, suggesting that FE-DBD-based plasma could be a potential therapeutic option for treating various wounds. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20939868
- Volume :
- 14
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Biomedical Engineering Letters
- Publication Type :
- Academic Journal
- Accession number :
- 177776849
- Full Text :
- https://doi.org/10.1007/s13534-024-00356-5