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Activation of the PPARγ/NF-κB pathway by A-MPDA@Fe3O4@PVP via scavenging reactive oxygen species to alleviate hepatic ischemia-reperfusion injury.
- Source :
- Journal of Materials Chemistry B; 6/21/2024, Vol. 12 Issue 23, p5722-5733, 12p
- Publication Year :
- 2024
-
Abstract
- Hepatic ischemia-reperfusion injury (IRI) is a common pathological process during hepatectomy and liver transplantation and the two primary reasons for hepatic IRI are reactive oxygen species (ROS)-mediated oxidative stress and excessive inflammatory responses. Herein, a novel antioxidant nanodrug (A-MPDA@Fe<subscript>3</subscript>O<subscript>4</subscript>@PVP) is prepared by employing L -arginine-doped mesoporous polydopamine (A-MPDA) nanoparticles as the carrier for deposition of ultra-small ferric oxide (Fe<subscript>3</subscript>O<subscript>4</subscript>) nanoparticles and further surface modification with polyvinylpyrrolidone (PVP). A-MPDA@Fe<subscript>3</subscript>O<subscript>4</subscript>@PVP not only effectively reduces the aggregation of ultra-small Fe<subscript>3</subscript>O<subscript>4</subscript>, but also simultaneously replicates the catalytic activity of catalase (CAT) and superoxide dismutase (SOD). A-MPDA@Fe<subscript>3</subscript>O<subscript>4</subscript>@PVP with good antioxidant activity can rapidly remove various toxic reactive oxygen species (ROS) and effectively regulate macrophage polarization in vitro. In the treatment of hepatic IRI, A-MPDA@Fe<subscript>3</subscript>O<subscript>4</subscript>@PVP effectively alleviates ROS-induced oxidative stress, reduces the expression of inflammatory factors, and prevents apoptosis of hepatocytes through immune regulation. A-MPDA@Fe<subscript>3</subscript>O<subscript>4</subscript>@PVP can further protect liver tissue by activating the PPARγ/NF-κB pathway. This multiplex antioxidant enzyme therapy can provide new references for the treatment of IRI in organ transplantation and other ROS-related injuries such as fibrosis, cirrhosis, and bacterial and hepatic viral infection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2050750X
- Volume :
- 12
- Issue :
- 23
- Database :
- Complementary Index
- Journal :
- Journal of Materials Chemistry B
- Publication Type :
- Academic Journal
- Accession number :
- 177815923
- Full Text :
- https://doi.org/10.1039/d4tb00423j