Back to Search
Start Over
Hydroxylamine‐Mediated C(sp2)−H Trifluoromethylation of Terminal Alkenes.
- Source :
- Chemistry - A European Journal; Jun2024, Vol. 30 Issue 33, p1-6, 6p
- Publication Year :
- 2024
-
Abstract
- Introduction of the trifluoromethyl (CF3) group into organic compounds has garnered substantial interest because of its significant role in pharmaceuticals and agrochemicals. Here, we report a hydroxylamine‐mediated radical process for C(sp2)−H trifluoromethylation of terminal alkenes. The reaction shows good reactivity, impressive E/Z selectivity (up to >20 : 1), and broad functional group compatibility. Expansion of this approach to perfluoroalkylation and late‐stage trifluoromethylation of bioactive molecules demonstrates its promising application potential. Mechanistic studies suggest that the reaction follows a radical addition and subsequent elimination pathway. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALKENES
RADICALS (Chemistry)
FUNCTIONAL groups
ORGANIC compounds
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 30
- Issue :
- 33
- Database :
- Complementary Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 177818845
- Full Text :
- https://doi.org/10.1002/chem.202400995