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Alpha-defensin binding expands human adenovirus tropism.
- Source :
- Genomics & Genetics Weekly; 6/21/2024, p196-196, 1p
- Publication Year :
- 2024
-
Abstract
- A recent preprint abstract suggests that alpha-defensins, which are peptides involved in the innate immune system, can enhance infection by certain bacterial and viral pathogens. The study found that exposure to alpha-defensins allows human adenoviruses (HAdVs) to bind to cells independently of known viral receptors, expanding their tropism to non-susceptible cells. This novel pathway for HAdV binding bypasses primary receptors and is integrin-dependent. The researchers propose that in the presence of sufficient concentrations of alpha-defensins, integrin expression rather than primary receptor expression will determine HAdV tropism in vivo. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]
- Subjects :
- ADENOVIRUSES
TROPISMS
IMMUNOLOGIC receptors
MEMBRANE proteins
DNA viruses
Subjects
Details
- Language :
- English
- ISSN :
- 15316467
- Database :
- Complementary Index
- Journal :
- Genomics & Genetics Weekly
- Publication Type :
- Periodical
- Accession number :
- 177869560