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Organic fertilization co-selects genetically linked antibiotic and metal(loid) resistance genes in global soil microbiome.
- Source :
- Nature Communications; 6/17/2024, Vol. 15 Issue 1, p1-13, 13p
- Publication Year :
- 2024
-
Abstract
- Antibiotic resistance genes (ARGs) and metal(loid) resistance genes (MRGs) coexist in organic fertilized agroecosystems based on their correlations in abundance, yet evidence for the genetic linkage of ARG-MRGs co-selected by organic fertilization remains elusive. Here, an analysis of 511 global agricultural soil metagenomes reveals that organic fertilization correlates with a threefold increase in the number of diverse types of ARG-MRG-carrying contigs (AMCCs) in the microbiome (63 types) compared to non-organic fertilized soils (22 types). Metatranscriptomic data indicates increased expression of AMCCs under higher arsenic stress, with co-regulation of the ARG-MRG pairs. Organic fertilization heightens the coexistence of ARG-MRG in genomic elements through impacting soil properties and ARG and MRG abundances. Accordingly, a comprehensive global map was constructed to delineate the distribution of coexistent ARG-MRGs with virulence factors and mobile genes in metagenome-assembled genomes from agricultural lands. The map unveils a heightened relative abundance and potential pathogenicity risks (range of 4-6) for the spread of coexistent ARG-MRGs in Central North America, Eastern Europe, Western Asia, and Northeast China compared to other regions, which acquire a risk range of 1-3. Our findings highlight that organic fertilization co-selects genetically linked ARGs and MRGs in the global soil microbiome, and underscore the need to mitigate the spread of these co-resistant genes to safeguard public health. In this study, the authors analyzed global metagenomic data from agricultural soils and show that organic fertilization co-selects for antibiotic and metal(loid) resistance genes in genomic elements, while metatranscriptomic data additionally provides evidence for co-regulation of these gene sets. [ABSTRACT FROM AUTHOR]
- Subjects :
- AGRICULTURAL exhibitions
AGRICULTURE
GENES
FARMS
ARSENIC
DRUG resistance in bacteria
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 15
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- 177950023
- Full Text :
- https://doi.org/10.1038/s41467-024-49165-5